Human Microbiome May Be Seeded Before Birth We... - Wissenschaft und Deutsch (on Hiatus)

Human Microbiome May Be Seeded Before Birth

We are each home to about 100 trillion bacteria, which we carry with us from birth till death. But when Juliette C. Madan was trained as a neonatologist in the mid-2000s, her teachers told her in no uncertain terms that we only acquire those bacteria after we are born. “It was clear as day, we were told, that fetuses were sterile,” she said.

Dr. Madan is now an assistant professor of pediatrics at the Geisel School of Medicine at Dartmouth, and she’s come to a decidedly different view on the matter. “I think that the tenet that healthy fetuses are sterile is insane,” she said.

Dr. Madan and a number of other researchers are now convinced mothers seed their fetuses with microbes during pregnancy. They argue that this early inoculation may be important to the long-term health of babies. And manipulating these fetal microbes could open up new ways to treat medical conditions ranging from pre-term labor to allergies.

In 1900, the French pediatrician Henry Tissier declared unborn babies bacteria-free. Only when they started their journey down through the birth canal did they begin to get covered with microbes. The newborns then acquired more as they were handled and nursed.

“This was considered a kind of scientific dogma,” said Esther Jiménez Quintana of Complutense University of Madrid.

This dogma gained strength from studies on babies born prematurely. Infections are a major risk factor in early labor. Many researchers saw this as evidence that the only bacteria in the uterus were dangerous ones.

But scientists came to this conclusion without finding out whether healthy fetuses had bacteria, too. “It became a self-fulfilling prophecy,” said Dr. Madan.

That has started to change in the past few years. In 2010, Josef Neu, a University of Florida pediatrician, examined the first stool from newborn babies, before they had their first meal. He found a diversity of bacteria in the stool, whether the babies were born on time or born prematurely.

“When we first saw this, we though it was an artifact,” said Dr. Neu. If the fetuses were indeed sterile, their stool should have been germ-free. But in follow-up studies, he has gotten the same results.

Other scientists have also found evidence indicating that healthy fetuses pick up bacteria in the womb. Dr. Quintana and her colleagues have found bacteria in the amniotic fluid of healthy babies, as well as in umbilical cord blood and placentas.

If other animals are any guide, we shouldn’t be surprised if human fetuses are laced with bacteria. In an essay published last week in the journal PLOS Biology, Seth R. Bordenstein and Lisa J. Funkhouser of Vanderbilt University observed that mothers transmitting bacteria to their offspring is the rule rather than the exception in the animal kingdom. Studying other species may give scientists clues about how human mothers inoculate their unborn children.

One open question is the route that bacteria take from mothers to their fetuses. A number of researchers suspect that immune cells in the mother’s intestines swallow up bacteria there and ferry them into the bloodstream, where they eventually wind up in the uterus.

It’s also not clear whether mothers deliver a random collection of species or a special set that are beneficial to them. Studies on children and adults have shown that our resident bacteria — collectively known as the microbiome — help us in many ways. They digest compounds in our food that would otherwise be indigestible.

Beneficial bacteria also help tutor the immune system, so that it attacks pathogens without overreacting and damaging the body itself. The microbiome can even fend off disease-causing bacteria.

read more 

  1. captainfrauleinmph reblogged this from scienceyoucanlove
  2. nyasanya reblogged this from eternalacademic
  3. eternalacademic reblogged this from effyeahmicrobes
  4. theboythatwaits reblogged this from effyeahmicrobes
  5. effyeahmicrobes reblogged this from scienceyoucanlove and added:
    I’m seriously thinking of doing a masters in developmental biology.
  6. itsonlyadreamalice reblogged this from scienceyoucanlove
  7. shockercombatman reblogged this from molecularlifesciences
  8. sciencetechengiesmath reblogged this from molecularlifesciences
  9. uwcdoverbiosoc reblogged this from molecularlifesciences
  10. rinsfidare reblogged this from molecularlifesciences
  11. raw-r-evolution reblogged this from dermoosealini and added:
    One day they will realize the universe is way more complex than the naked eye can see
  12. occasionalbutts reblogged this from molecularlifesciences
  13. emeraldmuse reblogged this from molecularlifesciences
  14. the-truth-is-somewhere reblogged this from molecularlifesciences
  15. dermoosealini reblogged this from molecularlifesciences
  16. molecularlifesciences reblogged this from scienceyoucanlove
  17. girl-behind-the-aura reblogged this from sluttyurlxo
  18. what-a-succulent-ass reblogged this from sagansense
  19. desidia5ever reblogged this from deadrevolutionaries
  20. deadrevolutionaries reblogged this from scienceyoucanlove
  21. biotechs reblogged this from chronicsci
  22. chronicsci reblogged this from scienceyoucanlove and added:
    Human Microbiome May Be Seeded Before Birth We are each home to about 100 trillion bacteria, which we carry with us from...
  23. reflections-in-water reblogged this from tullytubby